Zebra Sports NBA PACERS VS KNICKS PREDICTION, PICKS & BEST BETS FOR TONIGHT’S NBA PLAYOFFS GAME 1

PACERS VS KNICKS PREDICTION, PICKS & BEST BETS FOR TONIGHT’S NBA PLAYOFFS GAME 1



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Logan’s prediction: The Pacers will need Pascal Siakam to be big on the glass as they look to play spoiler at Madison Square Garden.

Jason Logan: Senior Betting Analyst at Covers

May 21, 2025 • 18:11 ET

• 4 min read

Photo By – Imagn Images. Indiana Pacers forwards Pascal Siakam and Obi Tobbin celebrate a win over the Cavaliers.

It’s time to renew a classic ’90s NBA rivalry. While it might not be “Reggie vs. Spike”, there won’t be any love lost in this year’s Eastern Conference Finals between the Indiana Pacers and New York Knicks. 

If Indiana is going to invade MSG — as those past Pacers teams did — it will need an all-out effort from power forward Pascal Siakam, the focal point of tonight’s Pacers vs. Knicks predictions.

I break down the Pascal Siakam odds in my NBA picks for Wednesday, May 21 below.

Who will win Pacers vs Knicks Game 1?

Sportsbooks have the Knicks listed as a two-bucket favorite, but Indiana has some different gears relative to New York’s last two foes. The Pacers will have fresh legs powering their frenzied approach, and I think they’re more than capable of pulling off the Game 1 upset inside MSG. Give me the underdog.

Prediction: Pacers will win.

Pacers vs Knicks prediction

My best bet: Pascal Siakam Over 6.5 rebounds (-135 at bet365)

Indiana Pacers forward Pascal Siakam continues to do the dirty work for the Pacers’ postseason push, averaging almost 19 points and more than six rebounds per game over 32 minutes of action.

Indiana is calling on Siakam to clean the glass against the New York Knicks after the Pacers were pushed around on the boards in the playoffs. New York really got after misses against Boston (rebound rate of 51.7%) while Indiana was undersized on the boards versus Cleveland, boasting a rebound rate of just 46%.

Siakam still averaged 6.4 rebounds over the five games with the Cavaliers with his advanced metrics showing 11.2 rebounding chances. Those possible boards could spike in this series with New York, considering the pace of play.

Indiana aptly wants to push the pace and boasted the fastest tempo in the conference semifinal round while the Knicks were drawn into the slowest series of Round 2 versus Boston. That uptick in tempo will produce more possessions and field goal attempts, upping the opportunities for rebounds.

Siakam, who has grabbed seven or more rebounds in four of his 10 postseason games so far, is drawing player projections between 7.8 and 8.8 boards in Game 1. The prop market is also showing confidence in Siakam to record seven or more rebounds, with his Over 6.5 climbing to as expensive as -145.

My number comes out to 7.8 rebounds which should have the Over 6.5 asking juice around -175. However, you can shop around and find the best value with Over 6.5 -135 at bet365.

Pacers vs Knicks same-game parlay

Pascal Siakam 7+ rebounds

Pascal Siakam 20+ points

Pacers +4.5

Siakam’s Game 1 forecasts all sit well above 6.5 boards with a ceiling close to nine.

Game 1 projections also like Siakam to score at least 20 points in what should be an up-and-down game.

I don’t think the Knicks are ready for the Pacers’ chaos on both ends and Indiana walks out of MSG with the cover as 4.5-point underdog.

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Pacers vs Knicks odds

Pacers vs Knicks live odds

Pacers vs Knicks opening odds

  • Spread: Indiana +4.5 (-110) | New York -4.5 (-110)
  • Moneyline: Indiana +155 | New York -185
  • Over/Under: Over 224 (-110) | Under 224 (-110)

Odds courtesy of bet365.

Pacers vs Knicks spread and Over/Under analysis

  • Oddsmakers installed New York as a 4.5-point home favorite for Game 1 of the Eastern Conference finals. That spread has bounced between that opener and -4 in the days leading up to tipoff.
  • The Over/Under total opened at 223 points and has jumped to 224 O/U with early opinions on the Over. These teams played Over in two of their three regular season encounters.
  • According to Covers Consensus, 64% of spread picks are taking the points with the Pacers while 60% of total picks are backing the Over in Game 1.

Pacers vs Knicks betting resources


Pacers vs Knicks trend

Indiana is 4-1 SU and ATS as the road team so far in the NBA Playoffs and 5-2 ATS as a point spread underdog. Find more NBA betting trends for Pacers vs. Knicks.

How to watch Pacers vs Knicks

Location Madison Square Garden, New York, NY
Date Wednesday, 5-21-2025
Tip-off 8:00 p.m. ET
TV TNT, truTV, max

Pacers vs Knicks latest injuries

Both teams enter tonight’s game relatively healthy with only Isaiah Jackson unable to perform. The 6-foot-10 center appeared in just five games this season for Indiana after tearing his right Achilles tendon on November 1.

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